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KMID : 0387420110220020085
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Korean Society of Oriental Neuropsychiatry
2011 Volume.22 No. 2 p.85 ~ p.105
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Studies on the Nootropic and Anti-amnestic and Anxiolytic-like Effects of G.J.D-P.P.A. in Mice
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Choi Chul-Hong
Kim Soo-Hyun
Chung Dae-Kyoo
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Abstract
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Objectives : The purpose of this study was to characterize the neuroprotective effects and anxiolytic-like effects of Gongjin-dan and Polygala japonica, Polygala tenuifolia, Acorus gramineus mixed pills(G.J.D-P.P.A.).
Methods :The neuroprotective effects of G.J.D-P.P.A. determined by the passive avoidance and Y-maze tasks and Morris water maze task, and the anxiolytic-like effects of the G.J.D-P.P.A. using an elevated plus-maze(EPM) in mice.
Results : Drug-induced amnesia was induced by treating animals with scopolamine(1 mg/kg, i.p.). A single G.J.D-P.P.A.(400 and 800 mg/kg) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks(P < 0.05) and also reduced escape-latency on the Morris water maze task(P < 0.05). The administration of GJD-PPA(400 and 800 mg/kg) significantly increased the percentage of time spent in open arms and entries into the open arms of the EPM compared with saline-treated control group(P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with saline-treated control group.
Conclusions : These results suggest that GJD-PPA dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and promotes the anxiolytic-like activity in mice.
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KEYWORD
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Gongjin-dan, Polygala japonica, Polygala tenuifolia, Acorus gramineus, Learning and memory, Anxiety
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